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How to differentiate Multiple myeloma from Waldenstrom macroglobulinemia?

Asked by Doctor Strange 

1. The peak incidence of Waldenstrom macroglobulinemia (WM) is 60-70 years whereas for multiple myeloma (MM), it is 50-60 years. 

2. The M spike in WM is IgM whereas in MM it is usually IgG (50%). 

3. The intensely eosinophilic plasma cells are classic for WM.