Asked by Anonymous
Central vagotonic effect (blocking M1 acetylcholine receptors in parasympathetic ganglion controlling SA node) of atropine which, at higher doses, is masked by muscarinic (M2 acetylcholine receptors) blockade at the sinoatrial node. The initial low dose of atropine may not be sufficient to ensure adequate peak concentration in peripheral tissues.
Further reading: Atropine Induced Paradoxical Bradycardia | Epomedicine
