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Why is the dosage of Linezolid 8 hourly in young children compared to 12 hourly in older children and adults?

Asked by Nosocomial

With the exclusion of pre-term neonates less than one week of age, clearance is most rapid in the youngest age groups ranging from >1 week old to 11 years, resulting in lower single-dose systemic exposure (AUC) and shorter half-life as compared with adults. As age of pediatric patients increases, the clearance of linezolid gradually decreases, and by adolescence mean clearance values approach those observed for the adult population.

Therefore, the dosage for pediatric patients up to 11 years of age should be 10 mg/kg q8h. Pediatric patients 12 years and older should receive 600 mg q12h.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021131s020lbl.pdf 

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