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Why fat embolism syndrome takes hours or days to develop?

Asked by Pramod

Fat embolism syndrome (FES) takes 2-96 hours to develop and usually 12-72 hours. This latent period or lucid interval in FES can be explained by the biochemical theory. However, both mechanical and biochemical theories seem mutually inclusive rather than exclusive.

Also, elevated serum IL-6 levels 12 hours after trauma correlated  with  an  increased  likelihood  of  developing FES.

Prakash S, Sen RK, Tripathy SK, Sen IM, Sharma RR, Sharma S. Role of interleukin-6 as an early marker of fat embolism syndrome: a clinical study. Clin Orthop Relat Res. 2013 Jul;471(7):2340-6. doi: 10.1007/s11999-013-2869-y. Epub 2013 Feb 20. Erratum in: Clin Orthop Relat Res. 2017 Mar;475(3):925. PMID: 23423626; PMCID: PMC3676609.

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