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Blood gas partition coefficients and MAC for inhalation gases

Asked by Dr. Aina

Higher partition coefficient = higher lipophilicity = higher potency = higher solubility
High solubility = more anesthetic needs to be dissolved = slower onset
MAC decreases as blood gas partition coefficient increases, generally speaking


Blood-gas partition coefficient
Brain-blood partition coefficient
Minimum alveolar concentration
 (
MAC
)
Nitrous oxide
  • 0.47
  • 1.1
  • > 104% 
Desflurane
  • 0.42
  • 1.3
  • 6–7%
Sevoflurane
  • 0.69
  • 1.7
  • 2%
Isoflurane
  • 1.40
  • 2.6
  • 1.4%
Enflurane
  • 1.80
  • 1.4
  • 1.7%
Halothane
  • 2.30
  • 2.9
  • 0.75%

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